Stathmin-2 (E3Y2N) Rabbit mAb (BSA and Azide Free) #42191

Filter:

ELISA

Supporting Data

REACTIVITY	M R
SENSITIVITY
MW (kDa)
Source/Isotype	Rabbit IgG

Application Key:

ELISA-ELISA

Species Cross-Reactivity Key:

M-Mouse
R-Rat

Product Information

Product Usage Information

This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

Formulation

Supplied in 1X PBS (10 mM Na₂HPO₄, 3 mM KCl, 2 mM KH₂PO₄, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

Storage

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

Specificity / Sensitivity

Stathmin-2 (E3Y2N) Rabbit mAb (BSA and Azide Free) detects endogenous levels of Stathmin-2.

Species Reactivity:

Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to a fragment of human Stathmin-2 protein.

Background

Stathmin is a family of microtubule-destabilizing phosphoproteins that play an important role in regulation of the microtubule cytoskeleton (1). The amino terminus of the protein contains multiple phosphorylation sites and is involved in the promotion of tubulin filament depolymerization. Phosphorylation at these sites inactivates the protein and stabilizes microtubules, regulating cellular processes, such as cell cycle and neuronal axon development (2). Stathmin family members include stathmin, stathmin-2, stathmin-3, and stathmin-4. Interestingly, stathmin-2 protein levels correlate with decreased TDP43 expression, an mRNA-binding protein that mislocalizes and aggregates in patients with the motor neuron disease, amyotrophic lateral sclerosis (ALS) (3). Interestingly, TDP43 directly regulates stathmin-2 expression by regulating STMN2 RNA splicing, suggesting that altered stathmin-2 expression might serve as a biomarker for disease progression or a therapeutic target.

Database Links

UniProt ID: Q93045

Entrez-Gene Id: 11075

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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