Syndecan 4 Antibody #12236
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 29 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Syndecan 4 is expressed ubiquitously and is enriched in the focal adhesions of various adherent cell types (5). Syndecan 4 controls focal adhesion formation and regulates cell migration through interaction with Rho family GTPase and protein kinase C family members (6-11). Phosphorylation of the cytoplasmic domain is linked to ectodomain shedding of Syndecan 4, both of which contribute to the regulation of cytokinesis (12).
- Couchman, J.R. (2003) Nat Rev Mol Cell Biol 4, 926-37.
- Multhaupt, H.A. et al. (2009) J Physiol Pharmacol 60 Suppl 4, 31-8.
- Zimmermann, P. and David, G. (1999) FASEB J 13 Suppl, S91-S100.
- Manon-Jensen, T. et al. (2010) FEBS J 277, 3876-89.
- Woods, A. and Couchman, J.R. (1994) Mol Biol Cell 5, 183-92.
- Harrington, E.O. et al. (1997) J Biol Chem 272, 7390-7.
- Oh, E.S. et al. (1997) J Biol Chem 272, 8133-6.
- Woods, A. and Couchman, J.R. (1992) J Cell Sci 101 ( Pt 2), 277-90.
- Longley, R.L. et al. (1999) J Cell Sci 112 ( Pt 20), 3421-31.
- Woods, A. et al. (2000) Arch Biochem Biophys 374, 66-72.
- Bishop, A.L. and Hall, A. (2000) Biochem J 348 Pt 2, 241-55.
- Keller-Pinter, A. et al. (2010) Cell Mol Life Sci 67, 1881-94.
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