TAB3 (D5J7D) Rabbit mAb #14241
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 82 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
TAK1-binding protein 3 (TAB3) is an additional binding partner for TAK1 and appears to be functionally redundant to TAB2 protein (9,10). The carboxy-terminal zinc finger domains in TAB2 and TAB3 bind to lysine 63-linked polyubiquitin chains within target proteins, including TRAF6, IKKγ, and RIP, which results in activation of IKK (11). Research studies also indicate that TAB2 and TAB3 proteins negatively regulate autophagy through interaction with beclin-1 (12,13).
- Yamaguchi, K. et al. (1995) Science 270, 2008-11.
- Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6.
- Shibuya, H. et al. (1996) Science 272, 1179-82.
- Sakurai, H. et al. (2000) FEBS Lett 474, 141-5.
- Takaesu, G. et al. (2000) Mol Cell 5, 649-58.
- Wang, C. et al. (2001) Nature 412, 346-51.
- Ge, B. et al. (2002) Science 295, 1291-4.
- Komatsu, Y. et al. (2002) Mech Dev 119, 239-49.
- Cheung, P.C. et al. (2004) Biochem J 378, 27-34.
- Jin, G. et al. (2004) Proc Natl Acad Sci U S A 101, 2028-33.
- Kanayama, A. et al. (2004) Mol Cell 15, 535-48.
- Takaesu, G. et al. (2012) J Biochem 151, 157-66.
- Criollo, A. et al. (2011) EMBO J 30, 4908-20.
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