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Render Timestamp: 2024-12-20T11:42:24.256Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:57:53.659
Product last modified at: 2024-12-17T19:05:10.181Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. TACI/TNFRSF13B/CD267 (E1D1P) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TACI/TNFRSF13B/CD267 (E1D1P) Rabbit mAb #96641

Filter:
  • WB
  • IP
  • IF
  • F

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 30-40
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100
    Immunofluorescence (Immunocytochemistry) 1:800 - 1:3200
    Flow Cytometry (Fixed/Permeabilized) 1:50 - 1:200
    Flow Cytometry (Live) 1:50 - 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TACI/TNFRSF13B/CD267 (E1D1P) Rabbit mAb recognizes endogenous levels of total TACI/TNFRSF13B/CD267 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human TACI/TNFRSF13B/CD267 protein.

    Background

    Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) and cluster of differentiation 267 (CD267), is a single-pass type III membrane receptor that is highly expressed on the surface of mature innate-like B cells, such as marginal zone and B-1 B cells in mice, and memory B cells in humans (1-3). TACI/TNFRSF13B/CD267 is also expressed on the surface of activated T cells (4), while monocytes and dendritic cells express lower levels of TACI/TNFRSF13B/CD267 primarily intracellularly (5,6). TACI/TNFRSF13B/CD267 is the receptor for soluble ligands BAFF/TNFSF13B and APRIL/TNFSF13 (7,8). Upon ligation, TACI/TNFRSF13B/CD267 recruits tumor necrosis factor receptor–associated factor (TRAF) family members and calcium signal-modulating cyclophilin ligand (CAMLG) in order to activate NFAT, NF-κB, and AP-1 transcriptional programs (9-11). TACI/TNFRSF13B/CD267 is necessary for T cell-independent type II and type I responses (1,12), negative regulation of B cell and T follicular helper cell numbers (13,14), and promotion of class switch recombination in B cells (15). Mutations and aberrant regulation of TACI/TNFRSF13B/CD267 has been associated with cancer, autoimmune diseases, and immunodeficiency disorders (16-18). Multiple isoforms produced by alternative splicing have been identified.
    1. von Bülow, G.U. et al. (2000) Mamm Genome 11, 628-32.
    2. Mantchev, G.T. et al. (2007) J Immunol 179, 2282-8.
    3. Tsuji, S. et al. (2011) Blood 118, 5832-9.
    4. Wang, H. et al. (2001) Nat Immunol 2, 632-7.
    5. Chang, S.K. et al. (2006) Blood 108, 2687-94.
    6. Chang, S.K. et al. (2008) J Immunol 180, 7394-403.
    7. Wu, Y. et al. (2000) J Biol Chem 275, 35478-85.
    8. Yu, G. et al. (2000) Nat Immunol 1, 252-6.
    9. Hymowitz, S.G. et al. (2005) J Biol Chem 280, 7218-27.
    10. Xia, X.Z. et al. (2000) J Exp Med 192, 137-43.
    11. von Bülow, G.U. and Bram, R.J. (1997) Science 278, 138-41.
    12. Ozcan, E. et al. (2009) J Allergy Clin Immunol 123, 1277-86.e5.
    13. Seshasayee, D. et al. (2003) Immunity 18, 279-88.
    14. Ou, X. et al. (2012) Proc Natl Acad Sci U S A 109, 15401-6.
    15. He, B. et al. (2010) Nat Immunol 11, 836-45.
    16. Castigli, E. et al. (2005) Nat Genet 37, 829-34.
    17. Moura, R.A. et al. (2013) J Rheumatol 40, 1293-302.
    18. Abo-Elfadl, M.T. et al. (2020) Cytokine 125, 154790.

    Database Links

    UniProt ID: O14836


    Entrez-Gene Id: 23495


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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