Render Target: STATIC
Render Timestamp: 2025-01-03T11:32:41.617Z
Commit: 286c369131ceeedcf44c821941824d8d7e009e57
XML generation date: 2024-08-01 15:25:43.189
Product last modified at: 2025-01-01T09:06:16.067Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

TAL1 Antibody #12831

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 50
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TAL1 Antibody recognizes transfected levels of total TAL1 protein.

    Species Reactivity:

    Human

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human TAL1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings (1). The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding (1). TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells (2), and is required for maturation of erythroid and megakaryocytic lineages in the adult (3). TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1 (4). Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL) (5,6). TAL1 activity is essential for both hematopoiesis and neurogenesis (7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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