TCF4 Antibody #2566
We recommend the following alternatives
#
Product Name
- WB
- IP
- ChIP
Inquiry Info. # 2566
Please see our recommended alternatives.
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 58, 79 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- ChIP-Chromatin Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Chromatin IP | 1:25 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
TCF4, also known as TCF7L2, is expressed widely during development. Gene targeting study indicates that it is required to maintain the crypt stem cells of the small intestine (5, 6). TCF4 has many different splicing isoforms and they are expressed differentially in tissues and in cancers of different stages (8, 9). Studies also indicate that variant of the TCF4 gene confers an increased risk of type 2 diabetes (10).
- Waterman, M.L. (2004) Cancer Metastasis Rev 23, 41-52.
- Schilham, M.W. and Clevers, H. (1998) Semin Immunol 10, 127-32.
- Brantjes, H. et al. (2002) Biol Chem 383, 255-61.
- Reya, T. and Clevers, H. (2005) Nature 434, 843-50.
- Logan, C.Y. and Nusse, R. (2004) Annu Rev Cell Dev Biol 20, 781-810.
- Cho, E.A. and Dressler, G.R. (1998) Mech Dev 77, 9-18.
- Korinek, V. et al. (1998) Nat Genet 19, 379-83.
- Howng, S.L. et al. (2004) Int J Oncol 25, 1685-92.
- Shiina, H. et al. (2003) Clin Cancer Res 9, 2121-32.
- Grant, S.F. et al. (2006) Nat Genet 38, 320-3.
Limited Uses
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