Render Target: STATIC
Render Timestamp: 2024-12-30T10:56:40.431Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:56:33.927
Product last modified at: 2024-12-17T19:01:50.237Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. TECPR1 (D6C10) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TECPR1 (D6C10) Rabbit mAb #8097

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 130
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TECPR1 (D6C10) Rabbit mAb recognizes endogenous levels of total TECPR1 protein. This antibody does not cross-react with TECPR2. A background band of unknown origin around 200 kDa is detected in some cell lines.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His900 of human TECPR1 protein.

    Background

    Tectonin β-propeller repeat protein (TECPR1) was first identified as DKFZP434B0335, a human ortholog of the yeast protein Pex23p (1). TECPR1 contains a pleckstrin homology (PH) domain, β-propeller domain, and dysferlin domains. Research studies have shown that elevated expression of TECPR1 may be a potential marker for prostate cancer (2). In several independent studies, TECPR1 was shown to play a role in autophagy through interaction with Atg5 (3-5). Atg5 is a protein that is conjugated to the ubiquitin-like protein Atg12 and plays an essential role in autophagy (6). Initial studies suggested that TECPR1 plays a role in selective autophagy processes by targeting bacterial pathogens, as well as damaged mitochondria and protein aggregates (4). TECPR1 appears to be important for autophagosome maturation and promotes autophagosome fusion with the lysosome (5). Deletion of TECPR1 leads to an accumulation of autophagosomes (5).

    Database Links

    UniProt ID: Q7Z6L1


    Entrez-Gene Id: 25851


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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