Tensin 2 Antibody #11990
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 145-155 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Tensin 2 is localized to focal adhesions of various tissues with highest expression in the heart, kidney, and liver (6,7). Tensin 2 inhibits Akt/PKB signaling via a phosphatase tensin-type domain (8). However, Tensin 2 also mediates thrombopoietin/c-Mpl signaling, which promotes Akt signaling (9). Interaction with Tensin 2 is essential for the tumor suppressor function of Deleted in Cancer 1 (DLC1) (6,10,11).
- Lo, S.H. et al. (1994) Bioessays 16, 817-23.
- Lo, S.H. et al. (1994) J Cell Biol 125, 1067-75.
- Chen, H. and Lo, S.H. (2003) Biochem J 370, 1039-45.
- Katz, M. et al. (2007) Nat Cell Biol 9, 961-9.
- Chen, H. et al. (2002) Proc Natl Acad Sci U S A 99, 733-8.
- Clark, K. et al. (2010) J Cell Biochem 109, 808-17.
- Hafizi, S. et al. (2002) Biochem Biophys Res Commun 299, 793-800.
- Hafizi, S. et al. (2005) FASEB J 19, 971-3.
- Jung, A.S. et al. (2011) Cell Cycle 10, 1838-44.
- Chan, L.K. et al. (2009) PLoS One 4, e5572.
- Chen, L. et al. (2012) J Biol Chem 287, 26104-14.
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