Render Target: STATIC
Render Timestamp: 2024-11-20T11:25:05.997Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:59:39.337
Product last modified at: 2024-11-04T09:30:13.168Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TEX264 (E2J3J) Rabbit mAb #44830

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 45
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TEX264 (E2J3J) Rabbit mAb recognizes endogenous levels of total TEX264 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro193 of human TEX264 protein.

    Background

    TEX264 (testis expressed gene 264) is a single-pass transmembrane protein localized to the endoplasmic reticulum (ER) that plays a key role in the clearance of damaged ER via the selective autophagic process of ER-phagy (1,2). It contains an LC3 interacting region (LIR) acting as a bridge from the ER to Atg8 family members, LC3 and GABARAP, on the autophagosome. Phosphorylation of TEX264 by casein kinase 2 can enhance its interaction with Atg8 family members (3). TEX264-mediated ER-phagy has been observed in pathological conditions, including acetaminophen-induced hepatotoxicity and in neuroinflammation associated with Alzheimer’s Disease (4,5). TEX264 has also been found to contribute to genomic stability through association with the VCP ATPase promoting TOP1-mediated DNA repair (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.