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Product last modified at: 2025-01-01T09:03:48.779Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TEX264 (E2J3J) Rabbit mAb #44830

Filter:
  • WB
  • IP
Western Blotting Image 1: TEX264 (E2J3J) Rabbit mAb
Western blot analysis of extracts from various cell lines using TEX264 (E2J3J) Rabbit mAb (upper) or GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). Low expression of TEX264 protein in HCC1806 cells is consistent with the predicted expression pattern.

To Purchase # 44830

Cat. # Size Qty. Price
44830T 20 µl
$168
44830S 100 µl
$371

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 45
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

TEX264 (E2J3J) Rabbit mAb recognizes endogenous levels of total TEX264 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro193 of human TEX264 protein.

Background

TEX264 (testis expressed gene 264) is a single-pass transmembrane protein localized to the endoplasmic reticulum (ER) that plays a key role in the clearance of damaged ER via the selective autophagic process of ER-phagy (1,2). It contains an LC3 interacting region (LIR) acting as a bridge from the ER to Atg8 family members, LC3 and GABARAP, on the autophagosome. Phosphorylation of TEX264 by casein kinase 2 can enhance its interaction with Atg8 family members (3). TEX264-mediated ER-phagy has been observed in pathological conditions, including acetaminophen-induced hepatotoxicity and in neuroinflammation associated with Alzheimer’s Disease (4,5). TEX264 has also been found to contribute to genomic stability through association with the VCP ATPase promoting TOP1-mediated DNA repair (6).
For Research Use Only. Not For Use In Diagnostic Procedures.
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