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Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-09-20 06:16:40.904
Product last modified at: 2024-09-13T07:01:45.560Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. Thimet oligopeptidase (IVD6) Mouse mAb

Thimet oligopeptidase (IVD6) Mouse mAb #4238

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Inquiry Info. # 4238

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    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 80
    Source/Isotype Mouse IgG2b
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:25

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Thimet oligopeptidase (IVD6) Mouse mAb detects endogenous levels of total Thimet oligopeptidase protein.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the amino-terminal region of Thimet oligopeptidase protein.

    Background

    Amyloid beta precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein containing the amyloid domain (A-beta). Beta-secretase is involved in proteolytic cleavage of APP releasing A-beta. The extracellular deposition and accumulation of the released A-beta fragments form the main components of amyloid plaques in Alzheimer's disease (1). Thimet oligopeptidase is a ubiquitously expressed metalloendopeptidase that was originally identified as a candidate beta-secretase (2). However, subsequent studies show that Thimet oligopeptidase promotes A-beta degradation. In addition, Thimet oligopeptidase inactivates a number of neuropeptides such as somatostatin, bradykinin, substance P and neurotensin (3). Finally, Thimet oligopeptidase has been shown both to increase and decrease presentation of antigenic peptides by the MHC-I at the cell surface. Despite these opposing results, there is consensus that Thimet oligopeptidase degrades peptides released by the proteasome (4-5).

    Database Links

    UniProt ID: P52888


    Entrez-Gene Id: 7064


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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