Render Target: STATIC
Render Timestamp: 2024-12-26T11:20:53.125Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:58:36.393
Product last modified at: 2024-12-17T18:55:20.624Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TIMM17A (E6F3I) Rabbit mAb #45948

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 18
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TIMM17A (E6F3I) Rabbit mAb recognizes endogenous levels of total TIMM17A protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro160 of human TIMM17A protein.

    Background

    TIMM17A (mitochondrial import inner membrane translocase subunit Tim17-A) is a component of the TIM23 mitochondrial transport complex, the main translocase of mitochondrial matrix proteins (1). TIMM17A is a potential biomarker and therapeutic target in breast cancer, as high expression is associated with aggressiveness and poor prognosis (2-4). TIMM17A was identified as one of eleven genes included in a gene signature predictive of CDK4 phosphorylation, and of sensitivity to the CDK4/6 inhibitor Palbociclib (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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