Render Target: STATIC
Render Timestamp: 2024-12-26T11:58:09.723Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:57:46.472
Product last modified at: 2024-12-18T21:15:14.577Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TIPE2 (E5Q2S) Rabbit mAb #53842

Filter:
  • WB
  • IP
  • IF
  • F

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 20
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunofluorescence (Frozen) 1:400 - 1:800
    Immunofluorescence (Immunocytochemistry) 1:400 - 1:1600
    Flow Cytometry (Fixed/Permeabilized) 1:800 - 1:1600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TIPE2 (E5Q2S) Rabbit mAb recognizes endogenous levels of total TIPE2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the sequence of human TIPE2 protein, including the carboxy terminus.

    Background

    Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TIPE2) is a negative regulator of innate and adaptive immunity, and is important in maintaining immune homeostasis. TIPE2 inhibits TGF-β activated kinase 1 (TAK1), a key regulator of inflammatory signaling (1). TIPE2 inhibits oncogenic Ras activity, and deficiency of TIPE2 is associated with resistance to cell death and increased cell migration (2). TIPE2 is downregulated in several human cancers, and may serve as a tumor suppressor and biomarker (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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