TORC1/CRTC1 (C71D11) Rabbit mAb #2587
- WB
Supporting Data
| REACTIVITY | M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 78 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
CRTC2/TORC2-related proteins CRTC1/TORC1 and CRTC3/TORC3 also act as CREB co-activators (2,3). CRTC1/TORC1, CRTC2/TORC2 and CRTC3/TORC3 associate with the HTLV Tax protein to promote Tax-dependent transcription of HTLV-1 long terminal repeats (6,7). CRTC1/TORC1 is highly phosphorylated at Ser151 in mouse hypothalamic cells under basal conditions (8). When these cells are exposed to cAMP or a calcium activator, CRTC1/TORC1 is dephosphorylated and translocates into the nucleus (8). CRTC1/TORC1 is essential for energy balance and fertility (8).
- Hinke, S.A. et al. (2004) J Physiol 558, 369-80.
- Conkright, M.D. et al. (2003) Mol Cell 12, 413-23.
- Iourgenko, V. et al. (2003) Proc Natl Acad Sci U S A 100, 12147-52.
- Screaton, R.A. et al. (2004) Cell 119, 61-74.
- Koo, S.H. et al. (2005) Nature 437, 1109-11.
- Koga, H. et al. (2004) J Biol Chem 279, 52978-83.
- Siu, Y.T. et al. (2006) J Virol 80, 7052-9.
- Altarejos, J.Y. et al. (2008) Nat Med 14, 1112-7.
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