Tox4 (E9U3L) Rabbit mAb (ChIP Formulated) #46419
- ChIP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- ChIP-Chromatin Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Chromatin IP | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Tox4 is a regulatory factor of PP1 phosphatases and plays important roles in transcription, which include restricting pause release and early productive elongation, facilitating transcriptional reinitiation, and promoting late productive elongation (3). Tox4 has been shown to modulate cell fate by reprogramming from a somatic state into a pluripotent and neuronal fate (4). Tox4 is a regulator of hepatic glucose production in an insulin receptor and FoxO1-independent manner, and its expression is increased in the liver in diabetic patients with nonalcoholic fatty liver disease (NAFLD) (5).
Limited Uses
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