TPBG/5T4 (E3M5R) XP® Rabbit mAb #17545
- WB
- IHC
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:100 - 1:400 |
| Flow Cytometry (Fixed/Permeabilized) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Research studies have demonstrated that TPBG is aberrantly overexpressed in numerous types of solid tumors (8) and functions to promote enhanced tumor cell motility and metastasis (9,10). In some tumors, such as NSCLC and HNSCC, TPBG has been identified as a novel marker of tumor-initiating cells (11,12). The observed differential expression of TPBG by normal tissue versus tumor tissue has been exploited by multiple immunotherapeutic agents that are currently being evaluated for targeting of multiple types of solid tumors (13).
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- Woods, A.M. et al. (2002) Biochem J 366, 353-65.
- Shaw, D.M. et al. (2002) Biochem J 363, 137-45.
- Awan, A. et al. (2002) Biochem Biophys Res Commun 290, 1030-6.
- Barrow, K.M. et al. (2005) Dev Dyn 233, 1535-45.
- Ward, C.M. et al. (2003) J Cell Sci 116, 4533-42.
- Ward, C.M. et al. (2006) Exp Cell Res 312, 1713-26.
- Southall, P.J. et al. (1990) Br J Cancer 61, 89-95.
- Carsberg, C.J. et al. (1996) Int J Cancer 68, 84-92.
- Myers, K.A. et al. (1994) J Biol Chem 269, 9319-24.
- Damelin, M. et al. (2011) Cancer Res 71, 4236-46.
- Kerk, S.A. et al. (2017) Clin Cancer Res 23, 2516-2527.
- Stern, P.L. and Harrop, R. (2017) Cancer Immunol Immunother 66, 415-426.
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