TRAF5 (D3E2R) Rabbit mAb #41658
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 64 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
TRAF5 regulates signaling through binding to the cytoplasmic domains of TNFR famly members including CD40, CD27, CD30, OX40, and lymphotoxin-β receptor (5-10). Overexpression of TRAF5 induces NF-κB activation. Cytoplasmic aggregates of TRAF5, as well as TRAF2, were reported in Hodgkin-Reed-Sternberg cells, resulting in constitutive NF-κB activation (11).
Studies of TRAF5 deficient mice suggest that it plays an important role in limiting Th2 immune responses that triggers T-cell mediated inflammatory diseases and asthma (12). Further studies indicate that TRAF5 binds to the IL-6 receptor gp130 and negatively controls Th17 differentation (13). In B-cells, TRAF5 negatively regulates toll-like receptor (TLR) mediated cytokine and antibody production (14).
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- Rothe, M. et al. (1994) Cell 78, 681-92.
- Nakano, H. et al. (1996) J Biol Chem 271, 14661-4.
- Ishida, T.K. et al. (1996) Proc Natl Acad Sci U S A 93, 9437-42.
- Aizawa, S. et al. (1997) J Biol Chem 272, 2042-5.
- Mizushima, S. et al. (1998) Gene 207, 135-40.
- Kawamata, S. et al. (1998) J Biol Chem 273, 5808-14.
- Nakano, H. et al. (1999) Proc Natl Acad Sci U S A 96, 9803-8.
- Horie, R. et al. (2002) Am J Pathol 160, 1647-54.
- So, T. et al. (2004) J Immunol 172, 4292-7.
- Nagashima, H. et al. (2014) Nat Immunol 15, 449-56.
- Buchta, C.M. and Bishop, G.A. (2014) J Immunol 192, 145-50.
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