TRAF6 (D21G3) Rabbit mAb #8028
- WB
- IP
To Purchase # 8028
| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 8028T | 20 µl | $145 | |
| 8028S | 100 µl | $339 |
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
- Related Products
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
TRAF6 plays a critical role in innate and adaptive immunity, bone metabolism, and development of certain tissues including the nervous system (5).TRAF6 deficiency results in osteopetrosis and defective IL-1, CD40, and LPS signaling (6) as well as defects in neuronal development (7). Unlike other TRAF family members that mediate signaling through TNF, TRAF6 has unique binding activities (8) that result in signaling responses from the interleukin-1 receptor (IL-1R) (9), toll-like receptor (10,11), CD40 (12), RANK (13,14), and p75 neurotrophin receptor (15). TRAF6 associates directly with CD40 and RANK, and indirectly with IL-1R/TLR through IRAK (10). This leads to activation of NF-κB and MAP kinase signaling pathways through downstream association with the TAB/TAK-1 complex (16). TRAF6 also activates Src family nonreceptor tyrosine kinases leading to Akt activation (17).
- Arch, R.H. et al. (1998) Genes Dev 12, 2821-30.
- Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88.
- Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91.
- Rothe, M. et al. (1994) Cell 78, 681-92.
- Wu, H. and Arron, J.R. (2003) Bioessays 25, 1096-105.
- Lomaga, M.A. et al. (1999) Genes Dev 13, 1015-24.
- Lomaga, M.A. et al. (2000) J Neurosci 20, 7384-93.
- Ye, H. et al. (2002) Nature 418, 443-7.
- Cao, Z. et al. (1996) Nature 383, 443-6.
- Muzio, M. et al. (1997) Science 278, 1612-5.
- Medzhitov, R. et al. (1998) Mol Cell 2, 253-8.
- Ishida, T. et al. (1996) J Biol Chem 271, 28745-8.
- Darnay, B.G. et al. (1998) J Biol Chem 273, 20551-5.
- Wong, B.R. et al. (1998) J Biol Chem 273, 28355-9.
- Khursigara, G. et al. (1999) J Biol Chem 274, 2597-600.
- Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6.
- Wong, B.R. et al. (1999) Mol Cell 4, 1041-9.
Pathways
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Limited Uses
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