Render Target: STATIC
Render Timestamp:
4/1/2025, 7:26:22 AM EDT
4/1/2025, 11:26:22 AM UTC
Commit: 461ca8d8fe5b1efd4c01fc87e5b5eb592e2d154a
XML generation date: 2025-03-07 13:20:21.261
Product last modified at: 2025-04-01T08:00:45.008Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. TRF1 (F6G3X) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TRF1 (F6G3X) Rabbit mAb #34872

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 60
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TRF1 (F6G3X) Rabbit mAb recognizes endogenous levels of total TRF1 protein. Based on the sequence of the peptide antigen, this antibody is expected to detect Pin2 isoform and not expected to detect TRF2 protein. By western blot and immunoprecipitation, this antibody detects an approximately 95 kDa protein of unknown identity in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala357 of human TRF1 protein.

    Background

    Telomeric Repeat-binding Factor 1 (TRF1) is one of six core proteins of the shelterin complex (TRF1, TRF2, Rap1, TIN2, POT1, and TPP1), which regulates telomere length and integrity. The shelterin complex localizes to telomeres and contributes to genomic stability by protecting telomeres from inappropriate processing by DNA repair pathways (1). Dysregulated expression of TRF1 promotes genomic instability and cancer progression in mice and humans. Both TRF1 and TRF2 are potential biomarkers and therapeutic targets in human cancer (2-4).

    Database Links

    UniProt ID: P54274


    Entrez-Gene Id: 7013


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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