Render Target: STATIC
Render Timestamp: 2024-12-20T11:49:08.077Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 02:00:09.178
Product last modified at: 2024-09-30T08:01:57.613Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TRIM7 (E3P2Q) Rabbit mAb #23567

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 57
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TRIM7 (E3P2Q) Rabbit mAb recognizes overexpressed levels of total TRIM7 protein. This antibody is predicted to detect multiple human TRIM7 isoforms.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala225 of human TRIM7 protein.

    Background

    E3 ubiquitin-protein ligase TRIM7 (TRIM7, RNF90, GNIP) is a member of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases that mediate protein degradation by the ubiquitin-proteasome system (1,2). The trim7 gene has four human isoforms and plays roles in metastasis of cancers, enterovirus replication, and the innate immune response (1-5). TRIM7 inhibits DNA virus-triggered innate immune responses by promoting ubiquitination and subsequent degradation of STING1 (3,6). TRIM7 targets mitochondrial antiviral signaling protein (MAVS) for degradation and negatively regulates antiviral responses against RNA viruses (4,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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