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Product last modified at: 2025-01-14T12:45:09.328Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Tyk2 Antibody #9312

Filter:
  • WB
Western Blotting Image 1: Tyk2 Antibody
Western blot analysis of extracts from Raji and Jurkat cells, using Tyk2 Antibody.

To Purchase # 9312

Cat. # Size Qty. Price Ships
9312S 100 µl
$378

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 134
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Tyk2 Antibody detects endogenous levels of total Tyk2 protein. No cross-reactivity was detected with other family members at physiological conditions.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding serine 819 of human Tyk2. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Tyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-α and β (1-3). Following ligand binding, Tyk2 is activated by phosphorylation of Tyr1054 and/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-β signaling cascade (5).

Pathways

Explore pathways related to this product.


For Research Use Only. Not For Use In Diagnostic Procedures.
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