UBE2C Antibody #14234
- WB
To Purchase # 14234
| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 14234S | 100 µl | $306 |
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 20 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
- Related Products
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Ubiquitin-conjugating enzyme 2C (UBE2C) is one of several ubiquitin conjugating enzymes participating in the E3 anaphase-promoting complex (APC/C). UBE2C is involved in the control of multiple stages of the cell cycle including inactivation of the mitotic spindle assembly checkpoint (2). UBE2C facilitates ubiquitin-dependent proteasomal degradation by initiating K11-linked ubiquitin chains on APC/C substrates (3). Research studies show that UBE2C expression is low in normal tissues, but its expression is dramatically upregulated in tumors derived from tissues such as lung, breast, and prostate (3-8). Overexpression of UBE2C in many types of solid tumors has been attributed to genomic amplification of the UBE2C locus and research studies have suggested that inhibition of UBE2C activity may have therapeutic potential (9).
- Hershko, A. (1988) J Biol Chem 263, 15237-40.
- Reddy, S.K. et al. (2007) Nature 446, 921-5.
- Wickliffe, K.E. et al. (2011) Cell 144, 769-81.
- Okamoto, Y. et al. (2003) Cancer Res 63, 4167-73.
- Berlingieri, M.T. et al. (2007) Eur J Cancer 43, 2729-35.
- Loussouarn, D. et al. (2009) Br J Cancer 101, 166-73.
- Wang, Q. et al. (2009) Cell 138, 245-56.
- Chen, Z. et al. (2011) EMBO J 30, 2405-19.
- Wagner, K.W. et al. (2004) Oncogene 23, 6621-9.
Alternate Names
UbcH10; UBE2; UBE2C; Ubiquitin Conjugating Enzymes; Ubiquitination
Limited Uses
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