UT-B/SLC14A1 (E3S8J) Rabbit mAb #44897

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	28-65
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

UT-B/SLC14A1 (E3S8J) Rabbit mAb recognizes endogenous levels of total UT-B/SLC14A1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala380 of human UT-B/SLC14A1 protein.

Background

Urea transporter B (UT-B, also known as UT1) is encoded by the SLC14A1 gene (1). Urea transporters (UTs) are multipass membrane proteins that transport urea down a concentration gradient. Urea is an organic compound composed of two amino groups and a linked carbamoyl group. Urea is a metabolic waste product of the liver and is excreted via the kidney. UT-B/SLC14A1 was first cloned from human erythrocytes (2). UT-B is not only expressed in endothelial cells of the renal medulla but is also expressed in other organs, including the brain, heart, and pancreas, suggesting broad physiological functions. In the brain, UT-B may be expressed in astrocytes to maintain urea concentrations in the central nervous system. Animals lacking UT-B exhibit depression-like behaviors, suggesting that regulation of urea levels in the brain may be important for proper neuronal function (3).

Database Links

UniProt ID: Q13336

Entrez-Gene Id: 6563

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For Research Use Only. Not For Use In Diagnostic Procedures.

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