Name: WFS1 Antibody
Price: 363.00 USD
Availability: InStock

Filter:

WB
IP

Supporting Data

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	100
SOURCE	Rabbit

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

WFS1 Antibody recognizes endogenous levels of total WFS1 protein.

Species Reactivity:

Human, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala43 of human WFS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) (1) and its expression is induced in response to ER stress, partially through transcriptional activation (2,3). Research studies have shown that mutations in the WFS1 gene lead to Wolfram syndrome, an autosomal recessive neurodegenerative disorder defined by young-onset, non-immune, insulin-dependent diabetes mellitus and progressive optic atrophy (4).

Database Links

UniProt ID: O76024

Entrez-Gene Id: 7466

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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WFS1 Antibody #8749