PTMScan® Succinyl-Lysine Motif [Succ-K] Kit #13764
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This product is intended for peptide enrichment and mass spectrometry analysis. To learn more about our Proteomics Kits and Services please answer a few questions for our Proteomics group.
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Background
Sirt 5 is a predominantly mitochondrial desuccinylase and demalonylase (5,6). In the absence of a known succinyltransferase, succinylation is likely driven by the concentration of succinyl-CoA and intracellular pH and is subject to metabolic fluctuations (7,8). Protein succinylation is especially prevalent among mitochondrial metabolic proteins and bacteria, further solidifying the evolutionary link between mitochondria and prokaryotes. It often occurs at lysine residues that are alternatively acetylated or ubiquitinated. More than a thousand lysine succinylation sites were identified on hundreds of proteins including glutamate dehydrogenase (15 sites), malate dehydrogenase, citrate synthase, carbamoyl phosphate synthase 1, and histone proteins (9).
- Liu, Z. et al. (2014) Nucleic Acids Res 42, D531-6.
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- Lin, H. et al. (2012) ACS Chem Biol 7, 947-60.
- Zhang, Z. et al. (2011) Nat Chem Biol 7, 58-63.
- Du, J. et al. (2011) Science 334, 806-9.
- Peng, C. et al. (2011) Mol Cell Proteomics 10, M111.012658.
- Rardin, M.J. et al. (2013) Cell Metab 18, 920-33.
- Park, J. et al. (2013) Mol Cell 50, 919-30.
- Weinert, B.T. et al. (2013) Cell Rep 4, 842-51.
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