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PTMScan® Wild Type Alpha-Lytic Protease (WaLP) #33036

    Product Information

    Product Usage Information

    PTMScan® Wild Type Alpha-Lytic Protease (WaLP) is provided for use with Cell Signaling Technology's patented PTMScan® protocol in the initial protein digestion step. Samples in urea lysis buffer need to be diluted to 2M or less urea prior to addition of WaLP. Dilute the 0.4 mg/ml stock 1:100 for final digest and incubate overnight at 37°C. Aliquot and store at -20ºC. Consult the specific PTMScan® kit and protocol for more details on the appropriate protease before digesting any protein samples.

    Storage

    This product is stable for 12 months when stored at -20°C. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Wild type alpha-lytic protease (WaLP) is a serine endopeptidase that cleaves at the carboxyl terminal side of alanine, serine, threonine, and valine amino acid residues.

    Specificity / Sensitivity


    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    All Species Expected

    Source / Purification

    WaLP was produced recombinantly in E. coli, purified and is provided in 10 mM sodium acetate pH 5.0.

    Background

    Wild type alpha-lytic protease (WaLP) was first isolated from myxobacterium Lysobacter enzymogenes (1). It is a protease that cleaves after A, S, T, and V residues making it a useful alternative protease for proteomics use. The pro-form of the enzyme is expressed as a 397 amino acid protein which is cleaved to a 198 amino acid mature protein. Numerous studies have been published about the mature form, active site, and catalytic mechanism (2, 3, 4). Based on crystal structure studies there seems to be a strong relation to other pancreatic serine proteases (5). The alternative cleavage specificity of WaLP is especially useful for looking at Proteomics of SUMO modifications as it cleaves the SUMO protein leaving a di-glycine motif that can then be detected using the proprietary SUMO Branch Motif remnant (K-ε-GG) antibody (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
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