PTMScan® Direct Tyrosine Kinases Service allows access to perform targeted screening and quantification of a defined set of protein sites within the tyrosine kinase branch of the kinome that are critical for drug discovery, biomarker discovery, or diagnostic development. The table below illustrates the list of protein sites that can be monitored with PTMScan® Direct Tyrosine Kinases Service.
Altogether, the PTMScan® Direct Tyrosine Kinase service provides a robust method to qualitatively identify and quantitatively profile 671 unique phosphorylation sites to 120 proteins.
| Tyrosine Protein Sites | |||
|---|---|---|---|
| Tyrosine Protein Sites | |||
| A6 iso2 (Tyr343) | A6 (Tyr309) | Abl iso2 (Tyr112) | Abl iso2 (Tyr134) |
| Abl iso2 (Tyr147) | Abl iso2 (Tyr158) | Abl iso2 (Tyr191) | Abl iso2 (Tyr204) |
| Abl iso2 (Tyr245) | Abl iso2 (Tyr251) | Abl iso2 (Tyr272) | Abl iso2 (Tyr276) |
| Abl iso2 (Tyr283) | Abl iso2 (Tyr412) | Abl iso2 (Tyr432) | Abl iso2 (Tyr488) |
| Abl (Tyr115) | Abl (Tyr128) | Abl (Tyr139) | Abl (Tyr172) |
| Abl (Tyr185) | Abl (Tyr215) | Abl (Tyr226) | Abl (Tyr232) |
| Abl (Tyr253) | Abl (Tyr257) | Abl (Tyr264) | Abl (Tyr393) |
| Abl (Tyr413) | Abl (Tyr469) | Abl (Tyr93) | Ack iso3 (Tyr596) |
| Ack iso3 (Tyr937) | Ack iso3 (Tyr938) | Ack iso3 (Tyr946) | Ack (Tyr284) |
| Ack (Tyr518) | Ack (Tyr859) | Ack (Tyr860) | Ack (Tyr868) |
| Ack (Tyr872) | Ack (Tyr874) | ALK (Tyr1078) | ALK (Tyr1092) |
| ALK (Tyr1096) | ALK (Tyr1131) | ALK (Tyr1278) | ALK (Tyr1282) |
| ALK (Tyr1283) | ALK (Tyr1359) | ALK (Tyr1507) | ALK (Tyr1584) |
| ALK (Tyr1586) | ALK (Tyr1604) | Arg iso4 (Tyr125) | Arg iso4 (Tyr403) |
| Arg (Tyr161) | Arg (Tyr174) | Arg (Tyr310) | Arg (Tyr439) |
| Arg (Tyr683) | Arg (Tyr718) | Arg (Tyr719) | Axl (Tyr696) |
| Axl (Tyr697) | Axl (Tyr698) | Axl (Tyr702) | Axl (Tyr703) |
| Axl (Tyr726) | Axl (Tyr755) | Axl (Tyr759) | Axl (Tyr866) |
| Blk (Tyr181) | Blk (Tyr182) | Blk (Tyr187) | Blk (Tyr188) |
| Blk (Tyr389) | Blk (Tyr494) | Blk (Tyr501) | Brk (Tyr114) |
| Brk (Tyr447) | Btk (Tyr223) | Btk (Tyr225) | Btk (Tyr334) |
| Btk (Tyr344) | Btk (Tyr361) | Btk (Tyr375) | Btk (Tyr511) |
| Btk (Tyr551) | CCK4 (Tyr872) | CLK3 (Tyr163) | CSFR (Tyr556) |
| CSFR (Tyr699) | CSFR (Tyr809) | CSK (Tyr263) | DDR1 (Tyr484) |
| DDR1 (Tyr513) | DDR1 (Tyr520) | DDR1 (Tyr790) | DDR1 (Tyr792) |
| DDR1 (Tyr794) | DDR1 (Tyr796) | DDR1 (Tyr797) | DDR1 (Tyr869) |
| DDR1 (Tyr881) | DDR2 (Tyr471) | DDR2 (Tyr481) | DDR2 (Tyr521) |
| DDR2 (Tyr735) | DDR2 (Tyr736) | DDR2 (Tyr739) | DDR2 (Tyr740) |
| DDR2 (Tyr741) | DYRK1A iso2 (Tyr136) | DYRK1A iso2 (Tyr312) | DYRK1A iso4 (Tyr145) |
| DYRK1A iso4 (Tyr321) | DYRK1A (Tyr145) | DYRK1A (Tyr321) | DYRK1B (Tyr273) |
| DYRK2 (Tyr382) | DYRK3 (Tyr369) | DYRK4 (Tyr264) | EGFR (Tyr1016) |
| EGFR (Tyr1069) | EGFR (Tyr1092) | EGFR (Tyr1110) | EGFR (Tyr1125) |
| EGFR (Tyr1138) | EGFR (Tyr1172) | EGFR (Tyr1197) | EGFR (Tyr727) |
| EGFR (Tyr827) | EGFR (Tyr869) | EGFR (Tyr998) | EphA1 (Tyr599) |
| EphA1 (Tyr605) | EphA1 (Tyr781) | EphA2 (Tyr575) | EphA2 (Tyr588) |
| EphA2 (Tyr589) | EphA2 (Tyr594) | EphA2 (Tyr595) | EphA2 (Tyr628) |
| EphA2 (Tyr694) | EphA2 (Tyr735) | EphA2 (Tyr772) | EphA2 (Tyr773) |
| EphA2 (Tyr921) | EphA2 (Tyr922) | EphA2 (Tyr930) | EphA2 (Tyr960) |
| EphA3 (Tyr123) | EphA3 (Tyr124) | EphA3 (Tyr596) | EphA3 (Tyr602) |
| EphA3 (Tyr736) | EphA3 (Tyr779) | EphA3 (Tyr937) | EphA4 (Tyr596) |
| EphA4 (Tyr602) | EphA4 (Tyr779) | EphA4 (Tyr798) | EphA5 (Tyr650) |
| EphA5 (Tyr656) | EphA5 (Tyr672) | EphA5 (Tyr790) | EphA5 (Tyr833) |
| EphA6 (Tyr787) | EphA6 (Tyr849) | EphA7 (Tyr608) | EphA7 (Tyr614) |
| EphA7 (Tyr791) | EphB1 (Tyr575) | EphB1 (Tyr582) | EphB1 (Tyr594) |
| EphB1 (Tyr600) | EphB1 (Tyr634) | EphB1 (Tyr778) | EphB1 (Tyr798) |
| EphB2 iso2 (Tyr596) | EphB2 iso2 (Tyr602) | EphB2 iso2 (Tyr780) | EphB2 (Tyr175) |
| EphB2 (Tyr181) | EphB2 (Tyr194) | EphB2 (Tyr577) | EphB2 (Tyr584) |
| EphB2 (Tyr585) | EphB2 (Tyr592) | EphB2 (Tyr596) | EphB2 (Tyr602) |
| EphB2 (Tyr604) | EphB2 (Tyr610) | EphB2 (Tyr780) | EphB2 (Tyr788) |
| EphB2 (Tyr912) | EphB3 (Tyr593) | EphB3 (Tyr595) | EphB3 (Tyr600) |
| EphB3 (Tyr603) | EphB3 (Tyr608) | EphB3 (Tyr609) | EphB3 (Tyr614) |
| EphB3 (Tyr754) | EphB3 (Tyr787) | EphB3 (Tyr792) | EphB3 (Tyr812) |
| EphB3 (Tyr919) | EphB3 (Tyr924) | EphB4 (Tyr574) | EphB4 (Tyr581) |
| EphB4 (Tyr590) | EphB4 (Tyr596) | EphB4 (Tyr614) | EphB4 (Tyr774) |
| EphB4 (Tyr906) | EphB4 (Tyr987) | EphB6 (Tyr628) | EphB6 (Tyr635) |
| EphB6 (Tyr637) | EphB6 (Tyr638) | EphB6 (Tyr644) | EphB6 (Tyr645) |
| EphB6 (Tyr651) | FAK iso2 (Tyr216) | FAK iso2 (Tyr226) | FAK iso2 (Tyr418) |
| FAK iso2 (Tyr424) | FAK iso2 (Tyr425) | FAK iso3 (Tyr397) | FAK iso3 (Tyr407) |
| FAK iso3 (Tyr570) | FAK iso3 (Tyr576) | FAK iso3 (Tyr577) | FAK iso3 (Tyr861) |
| FAK (Tyr397) | FAK (Tyr407) | FAK (Tyr441) | FAK (Tyr570) |
| FAK (Tyr576) | FAK (Tyr577) | FAK (Tyr608) | FAK (Tyr614) |
| FAK (Tyr615) | FAK (Tyr861) | FAK (Tyr899) | FAK (Tyr925) |
| FAK (Tyr936) | Fer (Tyr402) | Fer (Tyr714) | Fer (Tyr715) |
| Fes (Tyr156) | Fes (Tyr713) | FGFR1 (Tyr154) | FGFR1 (Tyr583) |
| FGFR1 (Tyr585) | FGFR1 (Tyr653) | FGFR1 (Tyr654) | FGFR1 (Tyr730) |
| FGFR2 (Tyr466) | FGFR2 (Tyr586) | FGFR2 (Tyr588) | FGFR2 (Tyr656) |
| FGFR2 (Tyr657) | FGFR2 (Tyr805) | FGFR2 (Tyr812) | FGFR3 (Tyr577) |
| FGFR3 (Tyr647) | FGFR3 (Tyr648) | FGFR4 iso3 (Tyr874) | FGFR4 iso3 (Tyr875) |
| FGFR4 (Tyr642) | FGFR4 (Tyr643) | Fgr (Tyr180) | Fgr (Tyr208) |
| Fgr (Tyr209) | Fgr (Tyr28) | Fgr (Tyr34) | Fgr (Tyr412) |
| Fgr (Tyr523) | FLT3 (Tyr589) | FLT3 (Tyr726) | FLT3 (Tyr842) |
| FLT3 (Tyr969) | FRK (Tyr104) | FRK (Tyr132) | FRK (Tyr221) |
| FRK (Tyr317) | FRK (Tyr368) | FRK (Tyr387) | FRK (Tyr46) |
| FRK (Tyr497) | FRK (Tyr504) | FRK (Tyr53) | FRK (Tyr99) |
| Fyn iso2 (Tyr213) | Fyn iso2 (Tyr214) | Fyn iso2 (Tyr417) | Fyn (Tyr185) |
| Fyn (Tyr213) | Fyn (Tyr214) | Fyn (Tyr28) | Fyn (Tyr339) |
| Fyn (Tyr420) | Fyn (Tyr440) | Fyn (Tyr531) | Hck (Tyr207) |
| Hck (Tyr209) | Hck (Tyr330) | Hck (Tyr409) | Hck (Tyr411) |
| Hck (Tyr51) | Hck (Tyr520) | Hck (Tyr522) | HER2 (Tyr1005) |
| HER2 (Tyr1127) | HER2 (Tyr1139) | HER2 (Tyr1248) | HER2 (Tyr735) |
| HER2 (Tyr877) | HER2 (Tyr878) | HER3 (Tyr1054) | HER3 (Tyr1156) |
| HER3 (Tyr1159) | HER3 (Tyr1197) | HER3 (Tyr1199) | HER3 (Tyr1262) |
| HER3 (Tyr1276) | HER3 (Tyr1286) | HER3 (Tyr1289) | HER3 (Tyr1307) |
| HER3 (Tyr1325) | HER3 (Tyr1328) | HER4 (Tyr1056) | HER4 (Tyr1128) |
| HER4 (Tyr1134) | HER4 (Tyr1268) | HER4 (Tyr1284) | HER4 (Tyr733) |
| IGF1R (Tyr1161) | IGF1R (Tyr1163) | IGF1R (Tyr1165) | IGF1R (Tyr1166) |
| IGF1R (Tyr1167) | IGF1R (Tyr1168) | IGF1R (Tyr1346) | IGF1R (Tyr1352) |
| IGF1R (Tyr577) | IGF1R (Tyr580) | InsR iso2 (Tyr1173) | InsR iso2 (Tyr1177) |
| InsR iso2 (Tyr1178) | InsR iso2 (Tyr1343) | InsR iso2 (Tyr1349) | InsR (Tyr1149) |
| InsR (Tyr1175) | InsR (Tyr1179) | InsR (Tyr1180) | InsR (Tyr1185) |
| InsR (Tyr1189) | InsR (Tyr1190) | InsR (Tyr1345) | InsR (Tyr1351) |
| InsR (Tyr1355) | InsR (Tyr1361) | ITK (Tyr146) | ITK (Tyr180) |
| ITK (Tyr198) | ITK (Tyr273) | ITK (Tyr40) | ITK (Tyr512) |
| JAK1 (Tyr1033) | JAK1 (Tyr1034) | JAK1 (Tyr1035) | JAK1 (Tyr220) |
| JAK2 (Tyr1007) | JAK2 (Tyr1008) | JAK2 (Tyr570) | JAK2 (Tyr790) |
| JAK2 (Tyr813) | JAK2 (Tyr931) | JAK2 (Tyr940) | JAK2 (Tyr956) |
| JAK2 (Tyr966) | JAK3 (Tyr785) | Kit (Tyr578) | Kit (Tyr703) |
| Kit (Tyr721) | Kit (Tyr730) | Kit (Tyr936) | Lck (Tyr192) |
| Lck (Tyr394) | Lck (Tyr505) | Lmr2 (Tyr1100) | Lmr2 (Tyr1448) |
| Lmr2 (Tyr1468) | Lmr3 (Tyr156) | LTK (Tyr672) | LTK (Tyr676) |
| LTK (Tyr677) | Lyn iso2 (Tyr172) | Lyn iso2 (Tyr173) | Lyn iso2 (Tyr376) |
| Lyn iso2 (Tyr487) | Lyn (Tyr117) | Lyn (Tyr193) | Lyn (Tyr194) |
| Lyn (Tyr265) | Lyn (Tyr266) | Lyn (Tyr306) | Lyn (Tyr316) |
| Lyn (Tyr32) | Lyn (Tyr397) | Lyn (Tyr460) | Lyn (Tyr473) |
| Lyn (Tyr501) | Lyn (Tyr508) | Mer (Tyr549) | Mer (Tyr744) |
| Mer (Tyr748) | Mer (Tyr749) | Mer (Tyr753) | Mer (Tyr754) |
| Mer (Tyr929) | Met (Tyr1003) | Met (Tyr1093) | Met (Tyr1228) |
| Met (Tyr1230) | Met (Tyr1232) | Met (Tyr1233) | Met (Tyr1234) |
| Met (Tyr1235) | Met (Tyr1349) | Met (Tyr1356) | Met (Tyr1365) |
| NPM-ALK (Tyr138) | NPM-ALK (Tyr152) | NPM-ALK (Tyr156) | NPM-ALK (Tyr191) |
| NPM-ALK (Tyr338) | NPM-ALK (Tyr567) | NPM-ALK (Tyr644) | NPM-ALK (Tyr646) |
| NPM-ALK (Tyr664) | PDGFRa (Tyr1018) | PDGFRa (Tyr572) | PDGFRa (Tyr574) |
| PDGFRa (Tyr613) | PDGFRa (Tyr731) | PDGFRa (Tyr742) | PDGFRa (Tyr754) |
| PDGFRa (Tyr762) | PDGFRa (Tyr768) | PDGFRa (Tyr849) | PDGFRa (Tyr944) |
| PDGFRa (Tyr958) | PDGFRa (Tyr962) | PDGFRa (Tyr988) | PDGFRb (Tyr739) |
| PDGFRb (Tyr771) | PDGFRb (Tyr778) | PIK3C2A (Tyr73) | PIK3C2B (Tyr1056) |
| PIK3C2B (Tyr127) | PIK3C2B (Tyr1541) | PIK3C2B (Tyr228) | PIK3C2B (Tyr68) |
| PIK3C2G (Tyr1437) | PIK3CA (Tyr317) | PIK3CA (Tyr508) | PIK3CB (Tyr246) |
| PIK3CB (Tyr425) | PIK3CB (Tyr503) | PIK3CB (Tyr504) | PIK3CB (Tyr505) |
| PIK3CB (Tyr772) | PIK3CB (Tyr956) | PIK3CB (Tyr962) | PIK3CD (Tyr484) |
| PIK3CD (Tyr485) | PIK3CD (Tyr524) | PIK3CD (Tyr935) | PIK3CD (Tyr936) |
| PIK3CG (Tyr757) | PIK3R1 (Tyr368) | PIK3R1 (Tyr452) | PIK3R1 (Tyr463) |
| PIK3R1 (Tyr467) | PIK3R1 (Tyr470) | PIK3R1 (Tyr508) | PIK3R1 (Tyr528) |
| PIK3R1 (Tyr556) | PIK3R1 (Tyr580) | PIK3R1 (Tyr607) | PIK3R2 (Tyr365) |
| PIK3R2 (Tyr443) | PIK3R2 (Tyr449) | PIK3R2 (Tyr453) | PIK3R2 (Tyr458) |
| PIK3R2 (Tyr461) | PIK3R2 (Tyr464) | PIK3R2 (Tyr467) | PIK3R2 (Tyr505) |
| PIK3R2 (Tyr599) | PIK3R2 (Tyr605) | PIK3R3 (Tyr195) | PIK3R3 (Tyr199) |
| PIK3R3 (Tyr202) | PIK3R3 (Tyr341) | PIK4CA iso3 (Tyr1059) | PIK4CA iso3 (Tyr1182) |
| PIK4CA iso3 (Tyr556) | PIK4CA iso3 (Tyr719) | PIK4CA (Tyr1096) | PIK4CA (Tyr1745) |
| PIK4CA (Tyr2032) | PIK4CA (Tyr470) | PIK4CA (Tyr633) | PIK4CA (Tyr973) |
| PIP5K1A iso2 (Tyr129) | PIP5K1A iso2 (Tyr333) | PIP5K1A iso2 (Tyr347) | PIP5K1A (Tyr142) |
| PIP5K1A (Tyr346) | PIP5K1A (Tyr360) | PIP5K1A (Tyr483) | PIP5K2A (Tyr246) |
| PIP5K2A (Tyr93) | PIP5K2B (Tyr167) | PIP5K2B (Tyr197) | PIP5K2B (Tyr98) |
| PIP5KG (Tyr136) | PIP5K (Tyr154) | PIP5K (Tyr1772) | PIP5K (Tyr1773) |
| PIP5K (Tyr324) | Pyk2 iso2 (Tyr579) | Pyk2 iso2 (Tyr580) | Pyk2 iso2 (Tyr777) |
| Pyk2 (Tyr402) | Pyk2 (Tyr579) | Pyk2 (Tyr580) | Pyk2 (Tyr683) |
| Pyk2 (Tyr699) | Pyk2 (Tyr722) | Pyk2 (Tyr819) | Pyk2 (Tyr849) |
| Ret (Tyr1062) | Ret (Tyr1096) | Ret (Tyr687) | Ret (Tyr900) |
| Ret (Tyr905) | Ron (Tyr1238) | Ron (Tyr1239) | Ron (Tyr1353) |
| Ron (Tyr1360) | ROR1 (Tyr160) | ROR1 (Tyr173) | ROR1 (Tyr786) |
| ROR1 (Tyr789) | ROR1 (Tyr828) | ROR1 (Tyr836) | ROR2 (Tyr666) |
| ROR2 (Tyr873) | ROS (Tyr1535) | ROS (Tyr1923) | ROS (Tyr2110) |
| ROS (Tyr2114) | ROS (Tyr2115) | ROS (Tyr2274) | ROS (Tyr2323) |
| ROS (Tyr2334) | ROS (Tyr2342) | Src (Tyr187) | Src (Tyr216) |
| Src (Tyr419) | Src (Tyr424) | Src (Tyr439) | Src (Tyr444) |
| Src (Tyr530) | Src (Tyr535) | Syk (Tyr203) | Syk (Tyr244) |
| Syk (Tyr296) | Syk (Tyr317) | Syk (Tyr323) | Syk (Tyr342) |
| Syk (Tyr346) | Syk (Tyr348) | Syk (Tyr352) | Syk (Tyr47) |
| Syk (Tyr525) | Syk (Tyr526) | Syk (Tyr568) | Syk (Tyr630) |
| Syk (Tyr631) | Syk (Tyr74) | TEC (Tyr228) | TEC (Tyr233) |
| TEC (Tyr518) | TIE2 (Tyr897) | Tnk1 (Tyr661) | TrkA iso2 (Tyr670) |
| TrkA (Tyr676) | TrkA (Tyr680) | TrkA (Tyr681) | TrkA (Tyr791) |
| TrkC iso2 (Tyr516) | TrkC iso2 (Tyr597) | TrkC iso2 (Tyr604) | TrkC (Tyr516) |
| TTK (Tyr374) | TTK (Tyr462) | TTK (Tyr833) | TTK (Tyr836) |
| Tyk2 (Tyr1054) | Tyk2 (Tyr1145) | Tyk2 (Tyr291) | Tyk2 (Tyr292) |
| Tyk2 (Tyr433) | Tyk2 (Tyr827) | Tyro3 (Tyr671) | Tyro3 (Tyr675) |
| Tyro3 (Tyr681) | Tyro3 (Tyr685) | Tyro3 (Tyr686) | Tyro3 (Tyr828) |
| VEGFR-1 (Tyr1048) | VEGFR-1 (Tyr1053) | VEGFR-1 (Tyr1213) | VEGFR-1 (Tyr1242) |
| VEGFR-1 (Tyr383) | VEGFR-1 (Tyr388) | VEGFR-1 (Tyr794) | VEGFR-2 (Tyr1054) |
| VEGFR-2 (Tyr1059) | VEGFR-2 (Tyr1214) | VEGFR-3 (Tyr1063) | VEGFR-3 (Tyr1068) |
| Yes (Tyr141) | Yes (Tyr146) | Yes (Tyr159) | Yes (Tyr194) |
| Yes (Tyr220) | Yes (Tyr221) | Yes (Tyr222) | Yes (Tyr223) |
| Yes (Tyr32) | Yes (Tyr343) | Yes (Tyr345) | Yes (Tyr424) |
| Yes (Tyr426) | Yes (Tyr444) | Yes (Tyr446) | Yes (Tyr535) |
| Yes (Tyr537) | ZAP70 (Tyr164) | ZAP70 (Tyr178) | ZAP70 (Tyr248) |
| ZAP70 (Tyr292) | ZAP70 (Tyr315) | ZAP70 (Tyr319) | ZAP70 (Tyr46) |
| ZAP70 (Tyr474) | ZAP70 (Tyr492) | ZAP70 (Tyr493) | ZAP70 (Tyr597) |
| ZAP70 (Tyr598) | ZAP70 (Tyr69) | ZAP70 (Tyr87) | |
